The location of cells positive for stem-like markers Msi, CD133, LGR5 and ALDH1 was expanded, often from the base to the middle part and occasionally to the top of the transitional crypt close to adenomas and CRCs (transitional crypt in adenomas, see Figure 2A, 2C, 2E and 2G; transitional crypt in CRCs, see Figure 2B, 2D, 2F and 2H). Here, LGR5 is linked to adenoma.