LGR5 and dysplasia: In the adenoma, the grading scores of LGR5 positive and ALDH1 positive cells were correlated with degree of dysplasia (low-grade dysplasia vs. high-grade dysplasia; LGR5: 1.26 ± 0.10 vs. 166 ± 0.12; ALDH1: 1.52 ± 0.11 vs. 1.98 ± 0.14; both P < 0.05 by the Mann–Whitney test), but not with histological types (data not shown).