LGR5 and colorectal carcinoma: In the CRC, the grading scores of both LGR5 positive and ALDH1 positive cells were associated with node involvement (node negative vs. node positive: LGR5, 1.44 ± 0.13 vs. 2.18 ± 0.24; ALDH1, 1.74 ± 0.13 vs. 2.40 ± 0.20: both P < 0.05 by the Mann–Whitney test).