LGR5 and colorectal carcinoma: In the CRC stroma, the grading scores of LGR5 positive and ALDH1 positive cells were not associated with TNM stages (NM stage I vs. II vs. III + VI: LGR5, 16.86 ± 1.87 vs. 15.18 ± 1.52 vs. 6.11 ± 2.45, P > 0.05; ALDH1, 18.71 ± 2.69 vs. 20.36 ± 2.16 vs. 18.78 ± 2.15, P > 0.05; both by the Kruskal-Wallis test).