Because fibroblasts are the main type of stromal cells and the activation of stromal fibroblasts are involved in the initiation and progression of CRC [23, 24], we examined the expression of fibroblasts labeled with vimentin with IHC and the proliferative activity of vimentin positive fibroblasts with double IHC in the adenoma/CRC stroma. This evidence concerns the gene VIM and adenoma.