When the cell positive for stem-like markers was analyzed against the clinical pathological parameters in the adenomatous/cancerous stroma, we have observed that the grading score of cell positive for LGR5 and ALDH1 was not associated with most clinical pathological parameters i.e. degree of dysplasia and histological types in the adenoma and TNM stage in the CRC. The gene discussed is LGR5; the disease is adenoma.