The results of double IHC demonstrated that many of the PCNA positive cells in the control (Figure 6A), adenoma (Figure 6B) and CRC (Figure 6C) stromal cells were vimentin positive fibroblasts and confirmed that vimentin positive fibroblasts in the adenoma/CRC stroma might have a high proliferative capacity. The gene discussed is VIM; the disease is colorectal carcinoma.