LGR5 and colorectal carcinoma: However, we have found that although the difference did not reach statistical significance, the density grading scores were higher in CRC patients with node involvement than those without (node negative vs. node positive: LGR5, 14.89 ± 1.20 vs. 18.00 ± 2.19; ALDH1, 18.00 ± 1.37 vs. 22.22 ± 2.59; both P < 0.05 by the Mann–Whitney test).