Both of LGR5 and ALDH1 grading scores were higher in CRC patients with advanced TNM stage than those with early stage (TNM stage I vs. II vs. III + VI: LGR5, 1.40 ± 0.17 vs. 1.43 ± 0.15 vs. 2.27 ± 0.26, P < 0.05; ALDH1, 1.60 ± 0.19 vs. 1.83 ± 0.16 vs. 2.29 ± 0.19, P > 0.05; both by the Kruskal-Wallis test). The gene discussed is ALDH1A1; the disease is colorectal carcinoma.