We found that compared to the shCtl/R1 cells, inhibiting p53 in ESCs (shp53/R1) partially rescued the G1-arrest and apoptosis caused by shAkt3d infection (Fig. 7A,B), although we also observed a near complete rescue of apoptosis when only a mild degree of cell apoptosis was induced (Fig. S4B,C). Here, TP53 is linked to infection.