AJAP1 and central nervous system cancer: It has been shown that the expression of AJAP1 is dysregulated in various cancer types including glioma (Lin et al., 2012; McDonald et al., 2006), hepatocellular carcinoma (HCC) (Ezaka et al., 2015) and esophageal squamous cell carcinoma (ESCC) (Tanaka et al., 2015).