After treatment with rSj-Cys, the sepsis-caused lung injury was improved and lung injury scores was much reduced compared to mice with sepsis without treatment, with the best results in group treated with 10 μg of rSj-Cys, which is consistent with the highest levels of IL-10 and TGF-β1 cytokines and lowest levels of pro-inflammatory cytokines in sera. This evidence concerns the gene TGFB1 and Sepsis.