IL10 and Sepsis: We found that 10 μg of rSj-Cys had the better therapeutic efficacy to reduce the severity of sepsis than the dose of 25 μg or 50 μg of rSj-Cys administrated, which is consistent with the higher levels of IL-10 and TGF-β1 and lower levels of pro-inflammatory cytokines in group of 10 μg rSj-Cys, possibly overdose of rSj-Cys saturates the effect on immune cells or blocks the receptors for other immunomodulatory factors.