Another recent publication reports that mDR and human DR5 promote K-Ras-driven cancer progression, invasion and metastasis since deficiency of mDR suppressed tumor growth and metastasis in K-Ras-driven carcinogenesis [13]; however, the results of this group are contradictory to their previous findings using a H-Ras-driven skin carcinogenesis model [6]. This evidence concerns the gene TNFRSF10B and cancer.