CCNB1 and ovarian cancer: When we examined the global transcriptional response of EOC cells to FOXM1 knockdown, we identified a large number of well-known cell cycle-related genes (CDC25B, CCNB1, CDK6, ASPM) in ovarian cancer [35–38], significantly down-regulated in both cell lines, coding for proteins structurally and functionally associated with the centromere-kinetochore complex, that were later validated by RT-qPCR.