In EOC-CC1 network, down-regulation of FOXM1 elicited expression of several pro-inflammatory cytokines (CCL20, CXCL8), markers of subtype and chemoresistance (PTHLH, TFAM), immune response mediators (TLR5, IRAK2), and perturbed genes involved in tumor-stromal interactions (COL1A1), tumor vascularity (F2R, HMGB1, NFATC3) and hypercalcemia (PTHLH). Here, HMGB1 is linked to Hypercalcemia.