Moreover, in EOC-CC1 cells, we verified the transcriptional down-regulation of a structural protein of the kinetochore, named CENPF, that acts synergistically with FOXM1 to promote tumor growth and metastasis in prostate cancer and co-regulates other downstream targets and signaling pathways associated with prostate malignancy [46]. The gene discussed is FOXM1; the disease is Familial prostate cancer.