REN and Primary hyperaldosteronism: Patients at high risk for OSA were almost two times more likely to have primary hyperaldosteronism (36% versus 19%, p < 0.05) with low plasma renin activity (1.2 ± 1.8 ng/mL/h versus 1.9 ± 4.1 ng/mL/h) and significantly greater 24 h urinary aldosterone excretion (13.6 ± 9.6 μg versus 9.8 ± 7.6 μg, p < 0.05) compared to participants at low risk of OSA, suggesting an association between primary hyperaldosteronism and OSA [21].