Further, Roark and co-workers [58], studying the binding of RA associated epitopes, including collagen II 258–272 and vimentin 66–78, for their capacity to bind DRB1*01 subtypes with differential associations with RA susceptibility, identified a role for the MHC B chain residue in position 86, associated with the P1 anchor, in disease susceptibility. The gene discussed is VIM; the disease is rheumatoid arthritis.