CDKN2A and neoplasm: Rs3731249 localizes to exon 2 of CDKN2A, being shared by both p16INK4A and p14ARF, the tumor suppressors codified by CDKN2A. For the p16INK4A, the C-to-T nucleotide substitution resulted in an alanine-to-threonine change (p.A148T).