Using the +/- 2kb window, TCF21 binding shows general enrichment near a wide range of GWAS SNPs for cardio-metabolic phenotypes (coronary heart disease, blood pressure and type 2 diabetes) as well as chronic inflammatory diseases (Crohns disease, multiple sclerosis, and rheumatoid arthritis), as well as skeletal phenotypes (bone mineral density) and in certain neurological disorders (bipolar disorder and schizophrenia). This evidence concerns the gene TCF21 and bipolar disorder.