TCF21 and multiple sclerosis: Using the +/- 2kb window, TCF21 binding shows general enrichment near a wide range of GWAS SNPs for cardio-metabolic phenotypes (coronary heart disease, blood pressure and type 2 diabetes) as well as chronic inflammatory diseases (Crohns disease, multiple sclerosis, and rheumatoid arthritis), as well as skeletal phenotypes (bone mineral density) and in certain neurological disorders (bipolar disorder and schizophrenia).