We have identified TCF21 as the causal gene at 6q23.2, characterized its mechanism of association, and shown that binding of this transcription factor is enriched in other CAD associated loci.[8, 12] To investigate how TCF21 interaction with other CAD loci may regulate disease risk, we have begun to study mechanisms of association in these loci. This evidence concerns the gene TCF21 and coronary artery disorder.