TP53 and hepatocellular carcinoma: We have previously shown that miR-483-3p is overexpressed in HCCs that carry mutations in β-catenin pathway genes3 and in HCCs with wild-type TP53, as compared with those with mutated TP53. 4 The miR is transcribed through the β-catenin (CTNNB1)/USF1 complex and targets the important downstream apoptotic factor of TP53, PUMA.3, 5 This gives to the miR a role in HCC tumorigenesis, based on the induction of resistance to apoptosis.