OGT and cancer: The reprogramming of glucose metabolism and its epigenetics aspects are relevant to the development of new approaches to cancer treatment.23, 24, 25 In this regard, the antitumoral effects of 2-DG are under intense study,26, 27 and we found that 2-DG treatment inhibits miR-483-3p expression in HepG2 cells, probably by reducing the OGT substrate, and equally enhances the apoptotic rate of HepG2 cells treated with 5-FU.