It has been reported that ME1 produces NADPH at levels as high as those produced by G6PD in the PPP shunt, which is a major cellular source of NADPH.10 ME1 levels are used as a prognosis and predictive marker for radiation therapy in cancer.11, 12 Therefore, ME1 is considered a promising target for cancer therapy and has been evaluated as such.13, 14. This evidence concerns the gene ME1 and cancer.