Previously, both Snail and Slug have been shown to inhibit ERα expression through transcriptional repression.24, 51 Here, we report a different mechanism for Slug to repress ERα expression through recruiting LSD1 to the E-boxes of ESR1 promoter and demethylating H3K4me2 in ERα-negative breast cancers. This evidence concerns the gene ESR1 and breast carcinoma.