ESR1 and breast carcinoma: The zinc-finger domain near the C-terminus of Slug binds to specific DNA sequences, the E-box motif (5′-CANNTG-3′), while its N-terminus has a SNAG domain that mediates transcriptional repression.47 For example, Slug represses E-cadherin expression through binding to its E-box motifs in breast carcinoma, resulting in the induction of EMT.48 In this study, we divided ESR1 promoter containing eight potential Slug-binding sites into three regions.