E3 ubiquitin ligases are involved in various cellular processes including cancer and inflammation.3, 50 Recently we have shown that Siah2 was induced by ETS2 and Twist1 in H. pylori-infected GCCs.51 It is therefore evident from the current study that ETS2 can simultaneously induce both Siah1 and Siah2 proteins in H. pylori-infected GCCs. This evidence concerns the gene SIAH1 and cancer.