SIAH1 and cancer: It is well established that loss of membrane-bound β-catenin enhances cancer invasiveness.30, 31, 32 Membrane-bound β-catenin loss is also frequent in metastatic gastric cancer cases.33 As we found that Siah1 could increase membrane-bound β-catenin degradation and it is also well known that H. pylori induces invasiveness of infected cells,34 we next wanted to assess the effect of Siah1 in increasing metastatic properties in GCCs.