Based on clinical observations, liraglutide reduces body weight (BW) in patients with T2D.8 In addition, liraglutide treatment augments weight loss in overweight and obese older individuals with prediabetes9 or without diabetes.10 Liraglutide binds to and activates the glucagon-like peptide-1 receptor (GLP-1R) that is the target of endogenous glucagon-like peptide-1 (GLP-1). Here, GLP1R is linked to diabetes mellitus.