A genetic association study of the AC3 gene in Swedish patients with T2D and obese subjects found that polymorphisms in the AC3 gene protect against obesity but are not associated with plasma glucose and insulin levels in patients with T2D.16 In our present study, liraglutide did not affect the FBG of the obese mice, and AC3 expression was not associated with the FBG and insulin levels. Here, ADCY3 is linked to obesity due to melanocortin 4 receptor deficiency.