IL6 and cardiovascular disorder: Using data from middle aged participants of the fifth decade follow-up of the Tasmanian Longitudinal Health Study (TAHS), we aimed to clarify interrelationships between NO2, systemic cytokines and specific cardiorespiratory condition by means of: (A) examining cross-sectional relationships between NO2 exposure and the pro-inflammatory cytokines, IL-6, IL-8 and TNF-α; and (B) examining for effect modification and/or mediation by post-bronchodilator (BD)-AO and cardiovascular disease.