OGG1 and neoplasm: In non-small cell lung carcinoma (NSCLC), a tumor type characterized by dysfunctional BER and low levels of OGG1 [23,24], MTH1 has been reported as the major determinant of genomic 8-oxoGua levels and is associated with low levels of G -> T transversions [25], a signature 8-oxoGua mutation due to its enhanced ability to pair with adenine.