Similar to the TH inhibitors [35] and our prior studies with MTH1 knockdown [30], MTH1 inhibition via (S)-crizotinib led to an increase in immunofluorescent staining for DSB-specific markers, such as 53BP1 and autophosphorylated ATM, in human colon carcinoma cells. This evidence concerns the gene NUDT1 and colon carcinoma.