HDAC1 and cancer: The blockade of statin-induced upregulation of GGTase-Iβ expression was further proven to be responsible for HDAC1 inhibitor enhancement of statin-induced anti-cancer effects, as the overexpression of exogenous GGTase-Iβ completely abolished this enhancement; in the presence of GGTase-I inhibitor GGTI-298, overexpression of GGTase-Iβ failed to abolish this enhancement.