Individuals participating in regular exercise training had lower serum testosterone, estradiol, and insulin levels compared to sedentary controls, and when these hormones were added to the serum of men in the intervention/exercise group to match the higher levels in the serum from the sedentary group, the reduction in prostate cancer cell growth originally seen in the exercise group was attenuated [29]. The gene discussed is INS; the disease is prostate carcinoma.