It is possible that IL-17 favors CXCL1 production in the brain endothelium in the early stages of MS and EAE, thus attracting neutrophils, inducing them to secrete pro-inflammatory cytokines including IL-1, TNF-α and IL-8, which subsequently provide entry for lymphocytes and monocytes [40]. Here, IL17A is linked to myeloid sarcoma.