Taken together, the down regulation of sLea [82] and Sda antigens, the up regulation of sLex [83] in colon cancer, and the persistent expression of some Lewis antigens in pancreatic cancer [54], appear as the consequence of a complex tissue- and cancer-specific regulation of several glycogenes operated by various epigenetic mechanisms. This evidence concerns the gene B4GALNT2 and colonic neoplasm.