WNK2 and Hepatic fibrosis: Additionally, an important cell signalling pathway, the mitogen-activated protein kinase (MAPK) pathway, and its subsidiary extracellular regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK), and p38 pathways, are involved in the aggravation of hepatic fibrosis; thus, these pathways may be targets for treating hepatic fibrosis [5].