The reduction of Co3 expression would lessen the number of infiltrating neutrophils in the lesions (which are the main producer of IL1β) and thus function as tumor suppression [19]; (3) The diminution of Anxa2 could downregulate another pro-inflammatory cytokine, TNFα, by the prevention of TNFα shedding in IBD [20]. This evidence concerns the gene MT-CO3 and inflammatory bowel disease.