The diminished hepatic steatosis in mice expressing low levels of both p53 and p63 in the liver was also consistent with the reduced levels of hepatic FAS, pJNK and ER stress markers such as pPERK and XBP1s (Fig. 5d), while no changes were found in protein levels of ApoB (Fig. 5d) or mRNA expression of CPT1, ACADM, ACADL and FATP2 (Fig. 5e). Here, TP53 is linked to fatty liver disease.