TNF and polyarticular arthritis: While hTNFtg and TNFΔARE models of polyarthritis are driven by a common pathophysiology, infliximab is not reported to cross react with murine TNFα.21 However, its efficacy has been reported in several murine models of chronic inflammation suggesting further modes of action beyond direct neutralization and depletion of TNFα.15, , , –19 These include the induction of T-cell apoptosis and suppression of angiogenesis, possibly mediated via Fc-mediated interactions and the natural immunogenicity of infliximab.21, , –24