Cg02219949 is located in the first intron of Sp6 transcription factor (SP6), a gene implicated in early development, cell proliferation, and previously associated with cognitive decline in Alzheimer Disease (Nakamura et al., 2014; Scohy et al., 2000; Sherva et al., 2014). This evidence concerns the gene SP6 and early-onset autosomal dominant Alzheimer disease.