IGF1 and cancer: Some research showed that BTG1 was upregulated in response to treatment with tomato leaf extract (TLE) [23], recombinant bromelain [24], and insulin-like growth factor I (IGF-I) [25] in the MCF-7 breast cancer cell line, which contained a SNP (rs764927448) in BTG1 by query of the Cancer Cell Line Encyclopedia (CCLE).