ERBB2 and breast cancer: Conversely, Tuna et al. showed that HER2/neu engages Akt to increase WT1 expression to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells, and then inhibition of HER2/neu with the anti-HER2/neu trastuzumab antibody decreased WT1 protein levels in HER2/neu-overexpressing BT-474 cells [26].