We first tested the expression of p-CREB, p-GSK3β, KLF5 and FGF-BP1 in a panel of breast cancer cell lines and found that p-CREB and p-GSK3β, KLF5 and FGF-BP1 are weakly or not expressed in non-TNBC cell lines compared with HCC1937 (Supplementary Figure S3). Here, CREB1 is linked to breast carcinoma.