This study also highlights a potential therapeutic role of TH and MH to modulate haematological parameters and the expression of Apaf-1, Caspase-9, IFN-γ, IFNGR1, p53, E2, ESR1, TNF-α, COX-2, and Bcl-xL in in vivo breast cancer model. Here, APAF1 is linked to breast carcinoma.