The mechanism by which TH and MH exert cancer-therapeutic effects is multifold, through modulation of immune response by ameliorating haematological and serological parameters and by activation of the intrinsic apoptotic pathway through upregulation of the expression of proapoptotic proteins such as Caspase-9, Apfa-1, p53, IFN-γ, and IFNGR1. Here, TP53 is linked to cancer.