Significant functional terms included “allergy” (increased: ANXA3, CFL1, CTSV, and KLK7; decreased: FLG and PPIA) and “differentiation of cells” (increased: CFL1, CTSV, and RPL22; decreased: FLG, PPIA, and VIM), suggesting that our FLG knockdown model displays many molecular characteristics typical of AE (Fig 4 and see Tables E3-E6). This evidence concerns the gene ANXA3 and allergic disease.