CFL1 and acrodermatitis enteropathica: Pathways associated with regulation of the actin cytoskeleton have been reported to be transcriptionally overrepresented in AE skin,13 and CFL1 mRNA expression is significantly upregulated in the involved skin of patients with AE, psoriasis, and lichen planus,48 suggesting that dysregulation of the actin cytoskeleton might be a contributing pathogenic mechanism.