KLK7 and Pruritus: KLK7 is highly expressed in skin,29 and its dysregulation has been implicated to AE pathogenesis; protein expression is increased in both involved and uninvolved AE skin and in the epidermis of flaky tail mice.29, 30, 31 Furthermore, overexpression of human KLK7 in murine models causes severe pruritus, increased epidermal thickness, and dermal inflammation.30