Similar functional annotations, specifically inflammatory and extracellular matrix dysregulation, have also been described in AE transcriptomic data sets,12, 13, 27 including those from FLG-null and haplosufficient patients with AE,12, 13 reinforcing the utility of our disease model and underscoring the central role of FLG deficiency in AE pathophysiology. Here, FLG is linked to acrodermatitis enteropathica.