A meta-analysis of prospective population-based studies found relative risks for coronary heart disease per 1-SD higher baseline levels of 1.13 (95% CI 1.06–1.21) with t-PA, 1.23 (1.16–1.32) with D-dimer and 1.16 (1.10–1.22) for VWF [58]. This evidence concerns the gene VWF and coronary artery disorder.