IL1B and Autoimmunity: With respect to inflammatory factors, there are a number of trials evaluating the effect of anti-inflammatory agents on cardiovascular outcomes, including low-dose methotrexate (a generic drug used to treat autoimmune conditions such as rheumatoid arthritis) and canakinumab (a human monoclonal antibody targeting the pro-inflammatory cytokine IL-1β) [39, 40, 50].