SNCA and infection: To determine if endogenous α-synuclein expression altered the outcome of a reovirus-T3D infection, including survival of the host and viral load in the brain, we infected littermates of three distinct genotypes, i.e., wt, Snca-heterozygous and Snca-null, using our established paradigm (Gauvin et al. 2013) (Fig. 4c).