As highlighted in serial sections of whole head mounts from pups at 10 dpi, once present in the brain parenchyma, reovirus-T3D infects multiple, vulnerable nuclei, thereby leading to prominent neuronal infection in the superior and inferior colliculi (tectum) of the midbrain (Fig. 3i), nuclei of the thalamus (Fig. 3j), regions of the pons and medulla oblongata, the hippocampus (not shown), and the cerebellum (Fig. 3k). Here, CD3D is linked to infection.