Specifically, given the role of α-synuclein in PD pathogenesis and the early detection of Lewy pathology in the OB during the prodromal phase of disease as per Braak and Del Tredici’s classification scheme (and the associated hyposmia), we probed for α-synuclein expression in the olfactory system in newborn (as young as P3) and aged (up to 24-month-old) mice. This evidence concerns the gene SNCA and Parkinson disease.