TLR9 and arthritic joint disease: Agonistic stimulation through TLR4 or TLR9 resulted in the decrease in diabetes, EAE and arthritis symptoms in mice, and the decrease in the expression of TLR9 in humans which led to increased morbidity to SLE (Buenafe and Bourdette 2007; Christensen et al. 2006; Lampropoulou et al. 2008; Quintana et al. 2000).