VEGF(R) introduced more neutropenia events and fatigue events than placebo (OR = 1.97, 95% CrI = 1.21–3.22; OR = 1.90, 95% CrI = 1.22–2.72), while TKI seemed to reduce the risk of fatigue for its superiority to all other drugs. This evidence concerns the gene VEGFA and neutropenia.