We used the TCGA and ICGC breast cancer data to identify frequency and type of mutations, and we found a number of new genes such as FLG, DNAH14, NBPF12, RYR2, ARHGAP35, OBSCN, CLTC, etc. are highly mutated in breast cancer, along with some well-known driver genes, like TP53, PIK3CA, MLL3, PTEN, GATA3, ARID1A. This evidence concerns the gene CLTC and breast cancer.