RIF1 and neoplasm: As shown in Figure 3E and 3F, miR-656-3p and RIF1 were significantly down-regulated in both tumor tissues and peripheral blood samples from patients with SCO, whereas FAM89A was significantly up-regulated in peripheral blood samples from patients with SCO compared with healthy individuals, but its expression did not significantly differ between SCO tumors and adjacent non-tumor tissues (Figure 3G).