Consensus groups convened by the American Heart Association and Canadian Stroke Best Practices recommend that cholinesterase inhibitors could be considered for use in VCI patients but with only intermediate‐grade evidence,5, 45 while the fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia recommends against using cholinesterase inhibitors in VCI patients unless there is comorbid AD.46 This evidence concerns the gene BCHE and Stroke.