BCHE and dementia: Additionally, the cholinesterase inhibitor donepezil was studied in a RCT in patients with cerebral autosomal dominant arteriopathy with subcortical ischemic leukoencephalopathy and cognitive impairment or dementia.32 In this study, 168 patients with cerebral autosomal dominant arteriopathy with subcortical ischemic leukoencephalopathy were randomized to donepezil 10 mg per day or placebo for 18 weeks.