CYP1A1 and amyotrophic lateral sclerosis: Bioinformatic analysis identified multiple AHR responsive elements (AHREs) in the promoter regions of the ALS-relevant gene TARDBP. Clusters of the consensus sequence “5′-GCGTG-3′” [44, 45], similar to those observed in the canonically AHR targeted metabolic genes CYP1A1 and CYP1B1, are present within 5000 base pairs of the transcription start sites (Fig. 5a).