Bioinformatic analysis identified multiple AHR responsive elements (AHREs) in the promoter regions of the ALS-relevant gene TARDBP. Clusters of the consensus sequence “5′-GCGTG-3′” [44, 45], similar to those observed in the canonically AHR targeted metabolic genes CYP1A1 and CYP1B1, are present within 5000 base pairs of the transcription start sites (Fig. 5a). This evidence concerns the gene CYP1B1 and amyotrophic lateral sclerosis.