In agreement, we have previously reported a dysregulated NF-κB/YY1/Snail/RKIP/PTEN loop detected in many cancers and showed that it promotes cell survival, proliferation, induces an epithelial to mesenchymal transition (EMT), potentiates invasion and metastasis, maintains drug/immune resistance, promotes anti-apoptotic mechanisms, and regulates the cancer stem cell phenotype [11, 12]. This evidence concerns the gene YY1 and cancer.