LEF1 and hepatocellular carcinoma: The inhibition of Wnt pathway by miR-4510 in Huh7 cells was accompanied by the decrease of associated genes including two transcriptional cofactors of β-catenin, such as LEF1 and TCF7L1 [27, 28], direct targets of Wnt/β-catenin signaling (IRS1, BMP4, FGF9 and LEF1), and various genes associated with poor-prognosis HCC such as BMP4, PDGFRA and SIX1 (Figure 7D).