To evaluate if these findings in the mouse model could be relevant for human situation, we next analyzed integrin-β1 expression in human tumor tissues and found it to be directly correlating with the level of Bgn, as shown for a representative patient with high Bgn/integrin-β1 expression (Figure 6A) compared to a different patient with low Bgn/integrin-β1 expression (Figure 6B). Here, BGN is linked to neoplasm.