siRNA-mediated knockdown of HIF-1α or HIF-2α selectively decreased expression of the respective protein in the three pancreatic cancer cell lines MiaPaca-2, SW1990, and Panc10.05; in the prostate cancer cell line DU145; and in the cervical cancer cell line HeLa (Figure 3a). Here, EPAS1 is linked to familial pancreatic carcinoma.