Somatic mutations in HIST1H1E, EZH2, and DNMT3A occur in hematological malignancies.26, 46, 47, 48, 49, 50HIST1H1E and EZH2 mutations are each present in ∼20% of B cell lymphomas.48, 49 Somatic HIST1H1E mutations are nonsynonymous mutations throughout the gene and do not include the clustered PTVs that cause OGID (Figure 5). Here, EZH2 is linked to hematologic disorder.