To further explore the phenotypic spectrum of OGID, we compared the growth and intellectual disability severity of the individuals due to mutations in the epigenetic regulation genes and those involved in the PI3K/AKT pathway, using case subjects for which the relevant phenotypic information was available (217 individuals with complete growth data and 263 individuals with intellectual disability severity information) (Figure 4). The gene discussed is AKT1; the disease is Intellectual disability.