Somatic mutations in HIST1H1E, EZH2, and DNMT3A occur in hematological malignancies.26, 46, 47, 48, 49, 50HIST1H1E and EZH2 mutations are each present in ∼20% of B cell lymphomas.48, 49 Somatic HIST1H1E mutations are nonsynonymous mutations throughout the gene and do not include the clustered PTVs that cause OGID (Figure 5). The gene discussed is DNMT3A; the disease is B-cell non-Hodgkin lymphoma.