Nishikawa et al. [26] reported that the GMPH score using 4 parameters [gamma-glutamyl transpeptidase, WFA(+)-M2BP, platelet count and hyaluronic acid] is useful for the detection of advanced liver fibrosis in patients with chronic hepatitis B. The present study demonstrated that the combination of serum miR-122 and WFA(+)-M2BP could predict advanced liver fibrosis in patients with HBV infection. This evidence concerns the gene GGTLC1 and chronic hepatitis B virus infection.