Interestingly, ITGA2B and integrin beta 3 (ITGB3) were found to be downregulated in PBMCs in infection by non-cytopathic bovine viral diarrhea virus (ncp BVDV) and upregulated by the cytopathic biotype (cp BVDV) in proteomic studies [66]. This evidence concerns the gene ITGA2B and infection.