Indeed, recently, Longo and coworkers have demonstrated that a fasting-mimicking diet (FMD) regime in combination with a standard chemotherapy, through the downregulation of HO-1 expression in tumor cells, enhances tumor immunogenicity by stimulating the levels of cytotoxic CD8+ tumor-infiltrating lymphocyte and decreasing the levels of Tregs, leading to a major delay in breast and melanoma progression [146]. This evidence concerns the gene CD8A and neoplasm.