Moreover, a growing body of evidence demonstrates the involvement of HO-1 in the generation of a favorable microenvironment, promoting angiogenesis and immune-escape in many types of cancers including melanoma, brain tumors, NSCL, prostate cancer, and chronic myeloid leukemia [66,67,68,69,70] and this aspect will be also described. This evidence concerns the gene HMOX1 and prostate cancer.