It has been also demonstrated that in lung mucoepidermoid carcinoma (MEC) the Nrf2-dependent HO-1 activation is associated with a tumor-suppressive phenotype characterized by a strong downregulation of MMP-9 and MMP-13 and the attenuation of the metastatic potential [105]. The gene discussed is HMOX1; the disease is pulmonary mucoepidermoid carcinoma.