Moreover, in neuroblastoma samples, the univariate Kaplan–Meier analysis revealed that high HO-1 RNA expression levels are associated with an unfavorable prognosis [147] and, in histological samples of human glioma, HO-1 expression was higher in comparison to non-malignant brain tissue [187] with no differences among the various tumor grades. The gene discussed is HMOX1; the disease is central nervous system cancer.