IFN-γ has also been reported to disrupt cholinergic signaling and secretory function in GCs and approximately 80% of patients with Sjögren syndrome, a systemic autoimmune disease that causes severe dry eye, develop anti-M3R autoantibodies that can also disrupt cholinergic signaling [22,23]. The gene discussed is IFNG; the disease is Keratoconjunctivitis sicca.