LHON cases are primarily identified with mutations in any of mitochondrial genes, including MT-ND1, MT-ND4, MT-ND4L, and MT-ND6, and over 95% of cases harbored one of three mtDNA point mutations, G3460A (ND1), G11778A (ND4), and T14484C (ND6), which encodes complex I subunits of the respiratory chain [44]. The gene discussed is MT-ND4; the disease is Leber hereditary optic neuropathy.