MADD is diagnosed with mutations in the alpha and beta subunits of electron transfer flavoprotein (ETFA and ETFB), ETF dehydrogenase (ETFDH), FAD synthase (FADS1), riboflavin transporters (SLC52A1-3), and mitochondrial FAD transporter (SLC25A32) [15,25,26,27,28]. The gene discussed is ETFDH; the disease is multiple acyl-CoA dehydrogenase deficiency.