Since our data established that Menin affected the expression of a large number of MYC target genes, such as CDK4 for cell cycle, LDHA and HK2 for glycolysis and SCD1 for lipid metabolism, we next performed experiments to determine the effects of Menin on MYC-mediated cell proliferation, glycolysis, lipid metabolism and tumour growth. This evidence concerns the gene CDK4 and neoplasm.