Notably, no significant TEAD expression differences were observed either between clinical liver cancer specimens and their adjacent normal liver tissues or between established liver cancer cell lines and hepatocyte lines (Fig. 1d–f), further demonstrating that O-GlcNAcylation likely exerts its pro-tumorigenic roles specifically via YAP but not by alerting YAP-dependent transcription factors. Here, YAP1 is linked to liver cancer.