Similarly, the levels of global O-GlcNAcylation and YAP were much higher in established liver cancer cell lines (SMMC-7721, Bel-7404, Bel-7402, HepG2, Huh7 and SK-Hep1) compared to non-cancerous hepatocyte lines, HL-7702 and THLE-3, and a positive correlation between YAP and global O-GlcNAcylation was also observed in liver cancer cell lines (Fig. 1f). This evidence concerns the gene YAP1 and liver cancer.